At the Department of Pharmacy, Uppsala University. Starting date 1st of October 2015 or as agreed upon. Information about the department and the research groups can be found at http://www.farmfak.uu.se/farm/.
The PhD project will be performed in professor Per Artursson´s research group, in collaboration with the Max-Planck Institute of Biochemistry in Martinsried, Germany and SciLifeLab. The group’s research take a multidisciplinary approach in order to understand how drugs are absorbed, distributed and eliminated in man and to understand how these mechanisms influence drug effects and adverse effects. In this PhD project, experimental as well as bio- and chemoinformatics, system biology and pharmacokinetic models will be used. The research group has 20+ members, most of which holds a PhD and eight are PhD students. The PhD student will be supported by senior scientists with relevant and complementary competences. More information about the research group can be found at http://www.farmfak.uu.se/farm/lmformul/index.html.
Project: Impact of transport mechanism on cellular drug permeability and exposure. Up to 70 % of all new drug targets are localized intracellularly. The aim with this PhD project is to investigate and quantify how drug transporting proteins influence the intracellular drug exposure to target and off-target proteins. New innovative experimental technologies developed in our group or by our world-leading collaborators will be used. Global and targeted proteomics will be combined with functional experiments at the cellular and tissue levels for precise determination of different drug transport processes and intracellular drug exposure. The data obtained will be analyzed with bio- and chemoinformatics, system biology and pharmacokinetic models. The specific aims of the project are 1) to develop a global model for the uptake of orally administered drugs from pharmacokinetic experiments and new global proteomics data of unsurpassed resolution from human intestine, 2) to investigate how transport mechanisms influences the uptake, intracellular concentration and exposure to a specific series of drugs and 3) to develop a mechanistic model that predicts drug exposure to a clinically relevant set of targets.
Qualifications: An MSc degree in a relevant field is required. The ideal candidate is highly motivated with thorough education and strong interest in the research field. Previous experience with experimental setups, the wet-lab, bioinformatics and computer modeling are beneficial. Candidates must be fluent in English.
Conditions: The PhD training comprises four years of full time research and studies. Since the position is combined with a 20% teaching assistantship the position is prolonged to five years. Information about education at the postgraduate level, admission requirements and admission decisions can be found at http://www.medfarm.uu.se/utbildning/forskarniva/.
The Postgraduate Programs Committee at the Disciplinary Domain of Medicine and Pharmacy will formally approve the student’s admission.
How to apply: The application should include a letter describing your research interests and motivation for PhD studies, a short description of your education, a CV, an authorized copy of your BSc/MSc degree(s), the names and contact information (address, email address, and phone number) of at least two reference persons, relevant publications (including MSc thesis).
For more information please contact Professor Per Artursson, e-mail: Per.Artursson@farmaci.uu.se phone +46 (0)18 4714471 (office) or +46 (0) 70 4250888 (cell).
Salary will be according to local guidelines at Uppsala University.
Application Deadline : 23 August 2015
Posted on 2015-08-12 03:12:06
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