A PhD position is available to study the crosstalk between the immune and endocrine system as well as the development of the thymus and associated immune parameters in juvenile D. labrax. using histological, molecular and biochemical methods and proteomics.
Description: Oestrogens have wide-ranging effects throughout life. In mammals, it is well known that oestrogens regulate thymic development and thymic atrophy, which may entail inhibition of T lymphopoiesis and result in suppressed humoral and cell-mediated immunity. Interestingly, oestrogen seems to alter lymphocyte apoptosis and activation, thus affecting T cell phenotypes.
This PhD thesis aims to investigate ontogenesis and alterations of the teleostean thymus and associated T lymphopoeisis in the context of oestrogen-exposure. The proposed project firstly intents to clarify whether a relation between oestrogen-dependent sexual development and thymus ontogenesis exists in teleosts and secondly, whether (environmental) oestrogens can alter thymus volume and structure and, consequently, thymus function in fish.
The research project, jointly funded by the Swiss national science Fondation (SNF) and the French Agence nationale de la Recherche Scientifique (ANR) is conducted in close collaboration with H. Segner at the Centre for Fish and Wildlife, Bern University, Switzerland. Two fish species, the European seabass (Dicentrarchus labrax) and the zebrafish (Danio rerio) with different developmental duration and reproductive strategies will be investigated. At the laboratory of Environmental Stress and Aquatic Biomonitoring the focus will be on seabass and its early life stages.
Candidates must hold a diploma/master degree in Biology or a comparable certificate. A wide knowledge of Immunology is required as well as competences in specific techniques (Proteomics, immunohistochemistry, flow cytometry). An interest in ecotoxicological problems will be appreciated. The project started January 2016 and the position will be available as of October 2016.
Please send your complete application including CV, letter of motivation, name and address of two referees via email (preferably single pdf file) to the address below before the 1st of July.
Dr. Tiphaine Monsinjon
UMR I-02 Environmental Stress
and Aquatic Biomonitoring
Le Havre University
25 rue Philippe Lebon, BP 1123
F-76063 Le Havre cedex
Tel. : +33 (0)2 32 74 43 24
Mail : firstname.lastname@example.org
Application Deadline : 1 July 2016
Posted on 2016-06-05 06:49:15
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