The Andersson lab is looking to recruit a highly motivated and talented PhD student to join our group working on computational biology with a strong focus on enhancers and transcriptional regulation. The successful candidate is expected to start January 1, 2017 or shortly thereafter.
The lab of Robin Andersson focuses on genomics and computational/statistical modeling of transcriptional regulation based on large-scale sequencing data, including experimental data generated from within the lab. We aim to characterize and better understand the architectures and complexities of transcriptional regulation (see e.g. Andersson et al. 2014, Nature, http://dx.doi.org/10.1038/nature12787 and gain insights into the mechanisms of regulation. We further focus on the fundamental properties of enhancers and promoters (see e.g. Andersson et al. 2015, Trends Genet,http://dx.doi.org/10.1016/j.tig.2015.05.007 as well as the biogenesis and characteristics of enhancer RNAs (see e.g. Andersson et al. 2014, Nat Comms,http://dx.doi.org/10.1038/ncomms6336. The group is also active in the international FANTOM consortium and is part of the FANTOM6 project http://fantom.gsc.riken.jp/6/. For more information, see http://anderssonlab.org
The correct function of regulatory elements and their interplay are essential for the precisely coordinated transcriptional activities within a cell. Disrupted regulatory activities may therefore have detrimental effects leading to disease. However, most variants have no or an only weakly associated trait and, in general, the impact of genetic variants on regulation is not well understood. Therefore, using our established accurate transcription-based method to assess activities of regulatory elements and the associations between them, we aim to systematically characterize human regulatory variation and its consequences. We further aim to infer models describing the function of a regulatory element and its importance, and thus the impact on regulation upon disruption.
The successful candidate is expected to work on projects related, but not limited, to 1) computational modeling of enhancer regulation and genome-wide mapping of enhancer architectures; and 2) assessment of the extent and impact of individual variation and genetic variants in regulatory architectures in order to understand their importance, stochasticity and robustness.
The scholarship requires a Master's degree in Bioinformatics or a field providing equivalent qualifications (see above), at the time of taking up the position.
The successful candidate should have a computational and/or statistical background and experience with analysis of large-scale data. Experiences with DNA or RNA sequencing data, genotyping data, statistical genetics, computational modeling, machine learning and/or statistical learning techniques are considered a major plus. Importantly, the candidate should have a strong interest in transcription and transcriptional regulation.
Specifically, the candidate should meet the following requirements:
The following are not required but considered a plus:
Place of employment
The Andersson lab is based in a highly collaborative environment in the Bioinformatics Centre in the Section for Computational and RNA Biology, which is currently composed of 11 strong research groups. The Department of Biology, University of Copenhagen, is located at the Biocenter in central Copenhagen, Denmark. Read more about the Andersson lab at http://anderssonlab.org
Applicants are requested to submit their application including:
After the expiry of the deadline for application, the authorized recruitment manager selects applicants for assessment on the advice of the interview committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant himself/herself.
The final selection of successful candidates will be made by the Head of Department, based on the recommendations of the assessment committee. Successful candidates will then be requested to formally apply for enrolment as a PhD student at the PhD school of the Faculty of Science, University of Copenhagen. For more information see:http://www.science.ku.dk/english/research/phd
Terms of salary and employment
Terms of salary and employment are in accordance with the agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC). The starting salary for candidates with an MSc degree will be a minimum of DKK 309,109 (April 2016 level) plus pension contribution, with the possibility of salary negotiation.
The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.
Application Deadline : 31 October 2016
Posted on 2016-10-01 09:10:57
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